2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-121815
    TDI-2760 956128-08-8 99.84%
    TDI-2760 is an Aβ aggregation inhibitor with an IC50 of 1.67 μM. TDI-2760 can inhibit the Aβ-fibrinogen interaction and Aβ aggregation, and also modulate the contact system activation induced by Aβ42. TDI-2760 can be used in research related to vascular abnormalities and Aβ aggregation in Alzheimer's disease.
    TDI-2760
  • HY-121920
    25C-NBOH hydrochloride 1539266-20-0 99.9%
    25C-NBOH hydrochloride is a derivative of 2C-C having an N-(2-hydroxybenzyl) addition at the amine and is a potent agonist of 5-HT receptors that shows selectivity for 5-HT2A over 5-HT2C (EC50s = ~ 0.40 and 15 nM, respectively).
    25C-NBOH hydrochloride
  • HY-122105
    JNJ-40255293 1147271-25-7 98.45%
    JNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease.
    JNJ-40255293
  • HY-124277
    ADM 12 1644134-60-0 98.86%
    ADM 12 is a highly selective transient receptor potential ankyrin 1 (TRPA1) channel antagonist. ADM 12 blocks nitroglycerin (NTG)-induced trigeminal hyperalgesia in animal models, reducing expression of pain-related genes (c-Fos, TRPA1) and neuropeptides (CGRP, SP). ADM_12 is promising for research of migraine and neuropathic pain.
    ADM 12
  • HY-124372
    JNJ-46356479 1254979-66-2 98%
    JNJ-46356479 is a selective and orally bioavailable mGlu2 receptor positive allosteric modulator (PAM), with the EC50 of 78 nM. JNJ-46356479 shows active in vivo.
    JNJ-46356479
  • HY-124463
    Epiallopregnanolone 567-01-1
    Epiallopregnanolone (5α,3β-THDOC), a 3β-hydroxy neurosteroid, an antagonist at GABAA receptors and a NMDA receptor enhancer.
    Epiallopregnanolone
  • HY-124609
    CAD031 2071209-49-7 99.39%
    CAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimer's disease (AD) targeted agent J147 (HY-13779) (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimer's disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice.
    CAD031
  • HY-124775
    (S)-C33 2066488-39-7 99.46%
    (S)-C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research.
    (S)-C33
  • HY-125111
    PSB-SB-487 1399049-81-0 98.01%
    PSB-SB-487 is a potent GPR55 antagonist and CB2 agonist with an IC50 value of 0.113 µM for GPR55, and a Ki value of 0.292 µM for human CB2. PSB-SB-487 can be used for researching diabetes, Parkinson’s disease, neuropathic pain, and cancer.
    PSB-SB-487
  • HY-12515C
    (R)-Nicardipine 76093-35-1 99.73%
    (R)-Nicardipine ((R)-YC-93 free base) is the less active R enantiomer of Nicardipine. Nicardipine (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure.
    (R)-Nicardipine
  • HY-125796
    U-14624 14901-16-7 99.67%
    U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes.
    U-14624
  • HY-125821
    Sigma-1 receptor antagonist 1 1639220-19-1 98.96%
    Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain.
    Sigma-1 receptor antagonist 1
  • HY-125953
    Ceramide (Egg) 477243-06-4 99%
    Ceramide (Egg) (Ceramide (Egg, Chicken)) is a ceramide from chicken. Ceramide (Egg) is a sphingomyelin signaling pathway second messenger. Ceramide (Egg) activates PP2A, JNK, p38 MAPK, CAPK, ceramide-activated protein phosphatase, Vav, PKCζ, and SAPK/JNK cascade. Ceramide (Egg) downregulates or inhibits AKT, survivin, CDK2, mTOR, and FLIP. Ceramide (Egg) mediates apoptosis, autophagy, cell cycle arrest, mitochondrial dysfunction, redox state shifts, and ROS generation. Ceramide (Egg) can be used for the research of cancer and neurological disease.
    Ceramide (Egg)
  • HY-126025
    α-Phthalimidopropiophenone 19437-20-8 99.9%
    α-Phthalimidopropiophenone is a drug derivative.
    α-Phthalimidopropiophenone
  • HY-126068
    Esamisulpride 71675-92-8 99.04%
    Esamisulpride ((S)-Amisulpride) is the S-isomer of Amisulpride (HY-14545). Esamisulpride is a potent dopamine D2/D3 receptor antagonist with Ki values of 4.43 nM for D2R and 0.72 nM for D3R. Esamisulpride is a 5-HT7 receptor antagonist with a Ki of 900 nM. Esamisulpride can be used in the research of schizophrenia and depression.
    Esamisulpride
  • HY-126112
    Mephenoxalone 70-07-5 98.57%
    Mephenoxalone is a muscle relaxant with anti-anxiety activity. Mephenoxalone has neuropharmacologic activity in vivo. Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc.
    Mephenoxalone
  • HY-126432
    NRL-1049 dihydrochloride 1973494-17-5 99.20%
    NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 (ROCK2) inhibitor with an IC50 of 0.59 μM. NRL-1049 dihydrochloride shows selectivity for ROCK2 is 44 times that of ROCK1 (IC50 = 26 μM). NRL-1049 dihydrochloride can preserve the blood-brain barrier after acute injury.
    NRL-1049 dihydrochloride
  • HY-126719
    R-1 Methanandamide Phosphate 649569-33-5 98.0%
    R-1 Methanandamide Phosphate is a water-soluble prodrug analog of arachidonylethanolamide (AEA). AEA is an endogenous cannabinoid compound.
    R-1 Methanandamide Phosphate
  • HY-12707S
    Piribedil-d8 1398044-45-5 99.79%
    Piribedil-d8 is the deuterium labeled Piribedil, which is an antiparkinsonian agent.
    Piribedil-d8
  • HY-128128
    ASN04421891 570365-12-7 99.00%
    ASN04421891 is a GPR17 agonist with nanomolar EC50 and high specificity. ASN04421891 promotes oligodendrocyte precursor cell maturation to mature myelinating oligodendrocytes. ASN04421891 can be used for the research of cerebral ischaemia, cardiac ischaemia, renal ischaemia, cerebral trauma, multiple sclerosis, schizophrenia, depression, alzheimer's disease, alzheimer-like dementia, parkinson's disease, huntington's chorea, amyotrophic lateral sclerosis (ALS), neuroinflammatory disorders.
    ASN04421891
Cat. No. Product Name / Synonyms Application Reactivity